Family cluster of Middle East respiratory syndrome coronavirus infections.
Identifieur interne : 001F92 ( Main/Exploration ); précédent : 001F91; suivant : 001F93Family cluster of Middle East respiratory syndrome coronavirus infections.
Auteurs : Ziad A. Memish [Arabie saoudite] ; Alimuddin I. Zumla ; Rafat F. Al-Hakeem ; Abdullah A. Al-Rabeeah ; Gwen M. StephensSource :
- The New England journal of medicine [ 1533-4406 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Arabie saoudite, Coronavirus (), Coronavirus (isolement et purification), Humains, Infections à coronavirus (imagerie diagnostique), Infections à coronavirus (virologie), Maladies transmissibles émergentes (virologie), Moyen Orient, Mâle, Pneumopathie virale (imagerie diagnostique), Pneumopathie virale (virologie), Poumon (imagerie diagnostique), RT-PCR, Radiographie, Sujet âgé, Évolution de la maladie.
- MESH :
- imagerie diagnostique : Infections à coronavirus, Pneumopathie virale, Poumon.
- isolement et purification : Coronavirus.
- virologie : Infections à coronavirus, Maladies transmissibles émergentes, Pneumopathie virale.
- Adolescent, Adulte, Arabie saoudite, Coronavirus, Humains, Moyen Orient, Mâle, RT-PCR, Radiographie, Sujet âgé, Évolution de la maladie.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Communicable Diseases, Emerging (virology), Coronavirus (classification), Coronavirus (isolation & purification), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (virology), Disease Progression, Humans, Lung (diagnostic imaging), Male, Middle East, Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (virology), Radiography, Reverse Transcriptase Polymerase Chain Reaction, Saudi Arabia.
- MESH :
- classification : Coronavirus.
- diagnostic imaging : Coronavirus Infections, Lung, Pneumonia, Viral.
- isolation & purification : Coronavirus.
- virology : Communicable Diseases, Emerging, Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Adult, Aged, Disease Progression, Humans, Male, Middle East, Radiography, Reverse Transcriptase Polymerase Chain Reaction, Saudi Arabia.
Abstract
A human coronavirus, called the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in September 2012 in samples obtained from a Saudi Arabian businessman who died from acute respiratory failure. Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. Meanwhile, global concern rests on the ability of MERS-CoV to cause major illness in close contacts of patients.
DOI: 10.1056/NEJMoa1303729
PubMed: 23718156
Affiliations:
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Le document en format XML
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Since then, 49 cases of infections caused by MERS-CoV (previously called a novel coronavirus) with 26 deaths have been reported to date. In this report, we describe a family case cluster of MERS-CoV infection, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS-CoV infection after the hospitalization of an elderly male relative, who died of the disease. Twenty-four other family members living in the same household and 124 attending staff members at the hospitals did not become ill. MERS-CoV infection may cause a spectrum of clinical illness. Although an animal reservoir is suspected, none has been discovered. 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